| Pair Name | alpha-Mangostin, Gemcitabine | ||
| Phytochemical Name | alpha-Mangostin (PubChem CID: 5281650 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | alpha-Mangostin, Gemcitabine | |||
| Disease Info | [ICD-11: 2C13] | Gallbladder cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | PCNA | hsa5111 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | SREBF1 | hsa6720 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| Down-regulation | Expression | FASN | hsa2194 | |
| Down-regulation | Expression | ACACA | hsa31 | |
| In Vitro Model | GBC-SD | Gallbladder carcinoma | Homo sapiens (Human) | CVCL_6903 |
| NOZ | Gallbladder carcinoma | Homo sapiens (Human) | CVCL_3079 | |
| Result | α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades. | |||
| No. | Title | Href |
|---|---|---|
| 1 | α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades. J Cell Mol Med. 2020 Jan;24(1):760-771. doi: 10.1111/jcmm.14785. | Click |
